3.6 Expression of GSA1 genes bearing CysSer substitution mutants in the gsa2 mutant background We then constructed GSAAT At mutants in which the conserved Cys residues had been individually replaced by Ser, and assessed their stability, activity and redox states in a gsa2 background
In this context, targeting CoQ 10 oxidoreductases may represent a more clinically tractable strategy
each R 4 is independently selected from F, Cl, Br, I, CN, NO 2 , CF 3 , OR 9 , OCF 3 , NR 8 R 9 , C(O)R 10 , CO 2 R 9 , C(O)NR 8 R 9 , N(R 8 )C(O)R 10 , N(R 8 )CO 2 R 10 , NHS(O) 2 R 10 , S(O) 2 NR 8 R 9 , C 1 -C 6 alkyl, C 3 -C 6 cycloalkyl, C 1 -C 6 heteroalkyl, C 1 -C 6 haloalkyl, C 2 -C 7 heterocycloalkyl, C 6 -C 10 aryl, and C 3 -C 9 heteroaryl
in animal models it is associated with tendon, ligament and muscle repair, angiogenesis and cytoprotection