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The efficacy of liraglutide on weight management was subsequently surpassed by semaglutide, which, when administered weekly at a dose of 2.4 mg in obese patients without diabetes, resulted in a weight reduction of 12.4% compared to placebo in the STEP 1 study [46], and a reduction of 9.4% compared to liraglutide 3.0 mg in the STEP-8 study [47]

PMID 3722679

Potential Benefits in Type 2 Diabetes Though most research focuses on type 1 diabetes (where C-peptide is absent), some studies in type 2 diabetes also suggest that higher physiological C-peptide levels correlate with better kidney outcomes, hinting at protective roles even when endogenous production is present

The retatrutide dose increase may cause temporary GI effects