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Clinical trial results for retatrutide have exceeded even the high expectations set by tirzepatide, with Phase 2 data published in the New England Journal of Medicine in 2023 demonstrating weight loss approaching 24-25% of baseline body weight over 48 weeks in some dose groups - weight reductions comparable to those achieved with bariatric surgery and substantially exceeding pharmacological obesity treatments available just a few years ago

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References: Aman S et al (2021): Management of Organophosphorus Poisoning: Standard Treatment and Beyond

While more research is needed, preliminary studies suggest this combination approach may address multiple factors contributing to midlife weight changes