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Patients should always follow the specific instructions provided with any licensed transdermal medication, as optimal sites will vary depending on the formulation's characteristics and the manufacturer's validated application protocols as detailed in the product's Summary of Product Characteristics (SmPC) and Patient Information Leaflet (PIL)

In cases where headaches significantly impact quality of life despite optimization efforts, switching to an alternative agent or considering different therapeutic approaches may be necessary

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Highly restrictive diets may lead to deficiencies that make it difficult to heal after surgery