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Most non disease-specific guidelines suggest a daily or alternate day dose of 1000 g of intramuscularly B12 for 2 weeks and then a transition to a monthly regimen (Kramarz et al

Although the human body produces vitamin D in response to sun exposure, several recent studies have identified a surprisingly high prevalence of vitamin D deficiency in healthy adults living in Canada and the United States causing mood changes, bone loss, muscle cramps and weakness, bone and joint pain (especially in the lower back), and fatigue

This is the same supplement I use in my clinic

These situations require patience and sustained support rather than aggressive intervention