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Furthermore, we demonstrate that the ROS-FOXM1 signaling cascade drives NEDD4 expression, thereby stabilizing YAP1 and promoting astrocyte proliferation

Chen, S

Central nervous system effects All three receptor types activated by retatrutide have targets in the central nervous system that influence appetite regulation

Analysts believe the drug could emerge as another blockbuster for Lilly and touch peak sales levels similar to tirzepatide, which is currently a $35 billion asset for the company.