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[cited 2022 Oct 27]

Ueki S, Melo RC, Ghiran I, Spencer LA, Dvorak AM, Weller PF (2013) Eosinophil extracellular DNA trap cell death mediates lytic release of free secretion-competent eosinophil granules in humans

However, high doses can cause gastrointestinal distress, which is the last thing you need when tirzepatide is already challenging your digestive system

The insulin resistance in PCOS might also occur independently of body weight, due to inherited post-receptor defects in insulin signalling that affects metabolism and mitotic pathways, not only in classic insulin target tissues, such as skeletal muscle, liver, and adipose tissue, but also in the non-classical target tissues, such as pituitary and ovary [12, 16]