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In vivo, plasma half-life has been measured at 78 minutes suggesting that in the body, DSIP may complex with carrier proteins that protect it from rapid degradation, or exist as a component of a larger precursor molecule (whose gene and structure have not yet been identified)

A study shows that caffeine consumed in larger quantities close to bedtime can have an effect on the number of hours the body is able to sleep, as well as the quality and quantity of REM sleep