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Gambardella, J

In addition, real-world data suggest that patient engagement plays a crucial role in long-term success

Mucolytics such as dornase alfa (NCT04402944, phase II of recombinant human DNase I for COVID-19) and mannitol (NCT00251056, phase II of mannitol for cystic fibrosis) have been tested mainly to relieve mucus blockages, but they do not assist drugs breakthrough or controllability interact with the mucus effectively

While there is no absolute contraindication listed in the Summary of Product Characteristics (SmPCs) for either medication, the combination offers limited additional benefit due to their overlapping mechanisms