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NF-KB is sensitive to ROS, and it modulates the transcription of genes encoding endothelin-1, tissue factor, and thrombomodulin (198)

Current strategies focus not only on targeting the BBB endothelium but also on the effective transport of specific compounds across it and the subsequent targeted drug release at appropriate targets in the brain (32)

as are certain blood disorders like sickle cell anemia, beta-thalassemia, and other causes of hemolytic anemia (Shaffer 2018