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In this trial, CSF samples were taken, showing that the drug was able to cross the BBB and that 12 weeks after the trial had stopped, there was no drug present in the CSF anymore

However, this direct role remains unconfirmed and controversial (72)

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Moreover, TRE, a subtype of IF, has been associated with symptom alleviation in individuals with irritable bowel syndrome (IBS) and improvements in overall gastrointestinal health markers [82]