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Semaglutide has been extensively studied for its cardiovascular benefits, showing a significant reduction in major adverse cardiac events (MACE) such as heart attacks and strokes in patients with type 2 diabetes or obesity

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Glucagon-like peptide-1 (GLP-1)-based therapies improve all these variables but whether the dual GLP-1 / glucose-dependent insulinotropic polypeptide (GIP) agonist tirzepatide is superior to semaglutide in attaining therapeutic targets remains unclear