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The 2025 Nobel Prize in Physiology or Medicine is awarded to Joel Habener, Svetlana Mojsov, and Jens Juul Holst for their discovery and development of GLP-1based therapeutics, which have revolutionized the treatment of diabetes and obesity worldwide. Well

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Though unable to provide atomic-level detail offered by X-ray crystallography or NMR, these methods were the first to reveal that many functional proteins exist as a dynamic ensemble of conformations rather than a single fixed structure

Given the ex vivo endothelial-dependent dysfunction, we measured nitrite levels in plasma, cardiac, and liver specimens from each group