Au-Yeung, H.Y., Chan, J., Chantarojsiri, T
For pediatric patients, a study investigating liraglutide treatment in a male with a homozygous LOF MC4R variant (c.750_751del p.Ile251fsTer34) - accompanied by severe insulin resistance, non-alcoholic fatty liver disease, and obstructive sleep apnea - has also indicated therapeutic benefits [69]
In certain embodiments, the viscosity of the gel is in the range from about 100 to about 50,000 cP, about 100 cP to about 1,000 cP, about 500 cP to about 1500 cP, about 1000 cP to about 3000 cP, about 2000 cP to about 8,000 cP, about 4,000 cP to about 50,000 cP, about 10,000 cP to about 500,000 cP, about 15,000 cP to about 3,000,000 cP
But the mechanistic data is compelling enough that several research groups are exploring this avenue