It is widely researched for its interaction with intracellular antioxidant-defense systems, oxidative-stress regulation pathways, mitochondrial-support mechanisms, and cellular-maintenance processes
[DOI] [PMC free article] [PubMed] [Google Scholar] Nozaki H, Hozumi K, Nishimura T, Habu S (1996) Regulation of NK activity by the administration of bromocriptine in haloperidol-treated mice
Additional caution or monitoring may be appropriate in research settings involving: Active cancer- or tumor-related research models, where antioxidant-related pathways may influence cellular-response or treatment-response mechanisms Severe asthma or hypersensitivity-prone research models, as rare sensitivity-related observations have been reported in some experimental contexts Sulfur-sensitive research models, due to Glutathione containing a thiol (sulfur-containing) group Complex hepatic-function or detoxification-related investigations, where antioxidant modulation may influence oxidative-stress or liver-related biomarkers Research conditions, research amounts, protocol duration, administration frequency, and concurrent compounds may influence tolerability observations across experimental settings

The two reasons are that CBS is activated by estradiol and betaine (Bet), which is twice as high in females compared to males because the enzyme PEMT [Figure 1] is activated by a factor of 2.3 in menstruating females