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B12 is much more complicated, it requires specialized transportation as well as multiple conversion steps

Some usage-limiting properties of the designed peptides, including low selectivity and tumor cell uptake, poor tumor permeability and passing through the BBB in glioma cancer, and low plasma stability, can be improved by several techniques, such as intracellular delivery via the intracellular pathway, ligand-mediated tumor targeting, and nanoparticle-based drug delivery systems

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Summary of NICE guidance for GLP-1 receptor agonists and tirzepatide in adults (NG246 resource)