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Since fat builds up in the liver, it only decreases the bodys metabolic rate, making it impossible to lose weight even with a balanced diet and exercise

"The effects of recombinant human insulin-like growth factor-I and growth hormone on body composition in elderly women." J Clin Endocrinol Metab

This makes MOTS-c more targeted and less likely to produce off-target gastrointestinal side effects common with metformin

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