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Important Notes The points below are the ones most often lost when teduglutide is discussed as a gut-health peptide rather than as the narrow, closely supervised drug it actually is

Table 4: Reasons to use medication to lower uric acid Gout with more than two flares a year, whether due to overproduction of uric acid or difficulty excreting it Chronic visible collections of uric acid (tophi) High uric acid in the urine (over 800mg per 24 hours), especially if history of kidney stone Failure of other options to control the arthritis of gout (for example, failure of probenecid) When a person is receiving chemotherapy for a leukemia or a lymphoma and it is expected that many tumor cells will be killed (since one of the breakdown products of cells is purine which gets broken down to uric acid) iii

After 24 h, the mice were euthanized and evaluated for peptide adsorption and penetration analysis by histological examination

1C, D and Supplementary Fig