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Interestingly, greater benefits were seen in those with high compared to low homocysteine concentrations at baseline, suggesting the importance of lowering homocysteine levels in prevention of brain atrophy and cognitive decline (91-93)

Reconstitution Supplies Needed AOD-9604 lyophilized powder (typically 2 mg or 5 mg vials) Bacteriostatic water (sterile water with 0.9% benzyl alcohol preservative) Insulin syringes (typically 0.3 mL or 0.5 mL with 29-31 gauge needles) Alcohol prep pads Sharps disposal container Step-by-Step Reconstitution Protocol Step 1: Prepare Your Workspace Wash hands thoroughly with soap and water

Cleavage of the methyl ester presented a problematic step, inducing racemization and resulting in an ee of only 86%