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Tyler WJ, Zhang XL, Hartman K, Winterer J, Muller W, Stanton PK, Pozzo-Miller L

Examples include anticholinergic medications and opioid pain medications (e.g., hydrocodone, morphine) Metabolism and clearance Tirzepatide is metabolized by proteolytic cleavage of the peptide backbone, beta-oxidation of the C20 fatty diacid moiety and amide hydrolysis DOSING Dosage forms Single-dose pen and single-dose vials 2.5 mg/0.5 ml 5 mg/0.5 ml 7.5 mg/0.5 ml 10 mg/0.5 ml 12.5 mg/0.5 ml 15 mg/0.5 ml Kwikpen (each pen contains 4 doses) 4 doses of 2.5 mg: 10 mg/2.4 mL (4.17 mg/mL) 4 doses of 5 mg: 20 mg/2.4 mL (8.33 mg/mL) 4 doses of 7.5 mg: 30 mg/2.4 mL (12.5 mg/mL) 4 doses of 10 mg: 40 mg/2.4 mL (16.7 mg/mL) 4 doses of 12.5 mg: 50 mg/2.4 mL (20.8 mg/mL) 4 doses of 15 mg: 60 mg/2.4 mL (25 mg/mL) Multi-dose vial (each vial contains 4 doses) 4 doses of 2.5 mg/0.6 mL: 10 mg/2.4 mL (4.17 mg/mL) 4 doses of 5 mg/0.6 mL: 20 mg/2.4 mL (8.33 mg/mL) 4 doses of 7.5 mg/0.6 mL: 30 mg/2.4 mL (12.5 mg/mL) 4 doses of 10 mg/0.6 mL: 40 mg/2.4 mL (16.7 mg/mL) 4 doses of 12.5 mg/0.6 mL: 50 mg/2.4 mL (20.8 mg/mL) 4 doses of 15 mg/0.6 mL: 60 mg/2.4 mL (25 mg/mL) Dosing (adults and pediatric patients aged 10 - 17 years) Starting: 2.5 mg subcutaneously once weekly

Unlike female pattern hair loss, frontal fibrosing alopecia often affects the eyebrows and temporal scalp and can result in complete and permanent hair loss

There is no consistent evidence of increased thyroid cancer risk in humans to date