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She says social media is full of posts by people claiming to use obesity meds short term, as a kickstart to a diet saying, "'Oh, I'm just going to take these for a short time and then stop.'" But Kumar says these drugs were intended for medical use to treat the disease of obesity, not used to aid in cosmetic weight-loss

Chronic hyperglycemia-induced ROS overproduction, primarily derived from mitochondrial ETC leakage and NOX activation, leads to eNOS uncoupling due to BH4 oxidation, reducing NO bioavailability and impairing vasodilation ( 2 and mitochondrial ROS-mediated apoptosis ( Furthermore, due to a decrease in their destruction rate and/or a reduction in the production of CAT, SOD, and GPx, excess ROS promotes the deleterious changes associated with OS