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This process helps to combat toxic peroxides, maintain the intracellular reduced state, and prevent DNA and lipid peroxidation

In the 72-week study of more than 1,600 overweight or obese adults with Type 2 diabetes, those who received the 36-milligram highest dose of orforglipron on average shed 10.5% of their weight, or about 23 pounds, versus 2.2% for those who received a placebo, achieving the main goal of the trial

Failure of the inflammation resolution is a key pathological mechanism that drives the progression of numerous inflammatory diseases

Full details of the replication analysis methodology is provided in Supplementary Information