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The metabolism adapts as well

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dose-for-dose equivalence is not 1:1 Dosing frequency is typically once or twice daily Storage requirements depend on the formulation and should be confirmed with the compounding partner Because dose is formulation-specific and compounding preparations vary, physicians should work with their compounding partner to confirm the specific dose and protocol appropriate to the formulation they prescribe

Others dont see a difference until season changes, especially in sunnier states like California or Florida, where UV exposure quickly reactivates pigmentation