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J Nucl Med 48:736743 Krner M, Christ E, Wild D, Reubi JC (2012) Glucagon-like peptide-1 receptor overexpression in cancer and its impact on clinical applications

Mitocytosis is another mechanism in which mitochondria are eliminated from cells, and it differs from mitophagy

These findings in both LEADER and SUSTAIN-6 underscore the therapeutic potential across different classes of GLP-1RAs [43]

This non-peptide mechanism, elucidated through cryo-electron microscopy and published in the Proceedings of the National Academy of Sciences in 2020, overturned decades of pharmacological dogma that class B GPCRs could only be meaningfully activated by peptide ligands