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Many people are initially asymptomatic
However, long-term activation of an opioid receptor with either chronic use or abuse of opioids leads to highly undesirable and clinically significant side effects
8 BMC Gastroenterology (2014) A randomized, double-blind, placebo-controlled, multiple-dose, parallel-group trial to assess the effects of teduglutide on gastric emptying of liquids in healthy subjectsPMID 24517114
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