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These findings support the relevance of MGBA mechanisms in BD pathophysiology, implicating both immune and metabolic pathways as shown in Table 8, and are conceptually illustrated through the microbiotaimmunemetabolicbrain axis model (Figure 6

However, many exposers in todays world deplete glutathione levels such as alcohol, artificial sweeteners, tobacco smoke, acetaminophen/Tylenol, toxic metals like mercury, artificial food dyes, and many common household chemicals

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