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doi: 10.1038/s41467-022-28204-z 32

Seek prompt or urgent referral to a dermatologist if there are red-flag features, including: suspected scarring alopecia (indicated by pain, erythema, scaling, or pustules on the scalp)

For hair applications specifically, longer cycles of 12-16 weeks may be appropriate given the slow nature of hair regrowth, followed by 4-6 week breaks

Therapeutic strategies targeting this cycle -such as Nrf2 activators (sulforaphane), mitochondrial antioxidants (MitoQ), and AGE inhibitors (aminoguanidine)- highlight the dual role of OS as interventions early in DM, which can improve -cell function, while later-stage treatments primarily mitigate complications