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Side effects and safety comparison Greater efficacy often comes with greater side effects

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With the highest proportion of SGLT2i use at baseline (26.9%) in any GLP-1 RA CVOT, and concomitant use of both drugs rising to almost 50% by the end of the trial, our results provide important information on the independence of semaglutide cardiovascular efficacy and safety with or without concomitant SGLT2i use in a high-risk population with T2D

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