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10.1152/ajpendo.00551.2012

Parallel evolutionary pathways for glutathione transferases: Structure and mechanism of the mitochon-drial class kappa enzyme rGSTK1-1

A landmark 2023 study published in JAMA found that GLP-1 agonist users experienced increased risks of gastrointestinal adverse events (with gastroparesis risk elevated compared to patients using other diabetes medications), while a 2024 case report in PMC documented the strong relationship between semaglutide use and gastroparesis symptoms that resolved only after drug discontinuation