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And weight gain is often driven by multiple factors: hormones, insulin resistance, medications, sleep deprivation, stress, and muscle loss

Based on Phase 2 clinical trials, patients with T2DM who were inadequately managed with diet and exercise alone or were on a stable metformin regimen for at least 3 months before screening received once-weekly subcutaneous injections of tirzepatide at doses of 1 mg, 5 mg, 10 mg, or 15 mg for 26 weeks

The combination of declining estrogen, changing androgen ratios, and the metabolic stress of weight loss creates a perfect storm for follicular disruption