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In the Phase 3 REDEFINE 1 trial, cagrilintide monotherapy achieved 11.8% average weight loss over 68 weekscomparable to semaglutide but with a notably lower incidence of nausea and vomiting, making it a potential option for patients who dont tolerate GLP-1 medications well

score 4: in cortex total disintegration of the tissue and the hypothalamus, thalamus, and hippocampus large complete infarcts (75% of the area affected)

Now, the thing about second-order effects is that the first-order has to play out to some critical degree

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