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to 9 p.m.) has no effect ( One of the well-established effects of cortisol is the reduction of brain-derived neurotrophic factor (BDNF), which physiologically functions to inhibit appetite and food intake ( BDNF is highly polymorphic, and the most common genetic variation, rs6265 (Val66Met), has been associated with greater severity of coronary artery disease ( 3.4 Clinical implications and research gaps The aforementioned mechanisms underscore the importance of cautious implementation of IF strategies because of their potential links with cardiovascular risk