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Amphetamine enters presynaptic neurons by passive diffusion and through plasma membrane monoamine transporters, including the dopamine transporter (DAT) in dopaminergic neurons, the norepinephrine transporter (NET) in adrenergic neurons, and the serotonin transporter (SERT) in serotinergic neurons

Curcumin may help lower inflammatory signaling, with modest benefits in joint pain

Hypothesis-generating approaches Hypothesis-generating interventions rely on mechanistic reasoning or preliminary preclinical/clinical data, requiring further validation in humans

Additionally, CBT and mindfulness-based pain management have been shown to improve pain perception by reducing stress and enhancing coping mechanisms, making them valuable options for individuals recovering from substance dependence