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Three non-coding mutations in the HGF gene were found at the autosomal-recessive NSHI locus (DFNB39) in some Pakistani and Indian families (Schultz et al., 2009)

When p53 is inactivated, the accumulation of DNA damage leads to sustained senescence induction through p16 expression 29

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Unused pens should be refrigerated (2-8C), while in-use pens can be kept at room temperature (below 30C) for up to 56 days