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rxlist.com Austedo Keywords Valbenazine Trade Name: Ingrezza Drug Class: Rx of Tardive dyskinesia (monoamine depletor) Mechanism of Action: a selective competitive inhibitor of VMAT2, similar to tetrabenazine the monoamine vesicular monoamine uptake transporter (VMAT2) transports (loads) cytoplasmic monoamine neurotransmitters (dopamine, norepinephrine, histamine, serotonin) into presynaptic storage vesicles found in sympathetic nerve terminals

Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1

In five cases, statin rechallenge with pravastatin, rosuvastatin, or simvastatin was used instead of resumption of the original atorvastatin without subsequent recurrence of hepatitis (Table 1)

Oral (Capsule): For gastrointestinal studies, oral administration is preferred