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If hiccups persist despite firstline self-care and begin to interfere with eating, sleeping, or blood sugar control, a clinician may consider prescribing short courses of drugs such as metoclopramide, baclofen, gabapentin, or chlorpromazine under supervision, with attention to side effects and interactions

Structured eating helps reduce impulsive choices driven by heightened appetite

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For example, in studies with exendin-4, researchers observed reduced -synuclein aggregation and improved neuronal survival in the substantia nigra