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However, there is no established link between GLP-1 or GIP receptor agonists and thyroid cancer in humans, and the relevance of rodent C-cell findings to human thyroid physiology remains questionable due to species differences in C-cell distribution and GLP-1 receptor expression

Besides the well-known targets such as the inhibition of the mTOR signaling pathway, several additional metformin and phenformin targets (e.g., mGPDH, ATF3, STAT3, GSK3, cyclins) have been identified in other cancers (Thakur et al., 2019)