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Patients with specific FTO variants, for example, may show stronger appetite suppression with higher-dose semaglutide, while those with certain GIPR polymorphisms might benefit from tirzepatide's dual GLP-1/GIP mechanism

Some evidence-based guidelines support first-line use

(59-62) Ill be sure to let you know when I learn more about the status of NAC on the market

Recently, tirzepatide, a novel dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist, has demonstrated considerable efficacy in improving glycemic control and promoting weight reduction in patients with obesity (79)