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CONCEPT OF TWINCRETINS IN MANAGEMENT OF TYPE 2 DIABETES It has been postulated that the glucose-lowering effects of simultaneous GLP-1R agonism might help overcome resistance to GIP action in T2D, thus enabling greater glucose-lowering effects when combined

Tirzepatide is administered as a once-weekly subcutaneous injection, with doses typically starting at 2.5 mg for initiation (not for glycemic control)

It is important to distinguish between side effects directly attributable to the medication's pharmacological action and those arising from the broader context of weight management