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That study enrolled 3,417 adults with obesity or overweight and without type 2 diabetes, and showed a mean weight loss of 22.7% at 68 weeks in patients who remained on treatment

Discontinuation of GLP-1 receptor agonists before pregnancy or early during pregnancy was tied to more gestational weight and a higher risk for some adverse health outcomes, a study in JAMA Womens Health showed

In preclinical models, researchers are exploring effects on endothelial function, blood pressure, lipid profiles, and inflammatory biomarkers

Here is how the 2025 changes are most likely to affect those looking to use these weight loss medications