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doi: 10.3389/fimmu.2017.01239 Received 27 June 2017 Accepted 19 September 2017 Published 29 September 2017 Volume 8 - 2017 Edited by Anna Rubartelli, IRCCS AOU San Martino IST, Italy Reviewed by Cecilia Garlanda, Istituto Clinico Humanitas, Italy

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El intervalo mnimo de 4 semanas entre aumentos de dosis permite que el sistema gastrointestinal se adapte progresivamente, reduciendo significativamente la incidencia y severidad de efectos secundarios como nuseas, vmitos y diarrea