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These conditions of excessive lipid toxicity and metabolic load eventually lead to the accumulation of liver lipids, cell damage, inflammation, and fibrosis (187, 188)

Indeed, an important issue for the potential cognitive and mental health effects of GLP-1RAs, which our analysis cannot fully address, is whether these medications provide symptomatic relief only via their well-established cardiometabolic benefits, or by directly targeting physiopathological mechanisms behind cognitive and mental symptoms