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Bone and GLP-1R signalling Bone is a tissue with an apparent static structure but is truly dynamic and in constant remodelling throughout life, with bone resorption (mediated by osteoclasts) and bone formation (mediated by osteoblasts) occurring concomitantly [57]

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As we age, however, our natural production of these vital messengers often declines

To generate knockout mutants of GSTF11 (AT3G03190) and GSTU20 (AT1G78370) based on the CRISPR-Cas9 system, the online website CRISPR-PLANT was used to design the gRNA spacer sequences ( Agrobacteria strain GV3101 and subjected to the floral dipping method