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The 2004 Bissett study in International Journal of Cosmetic Science used twice-daily 5 percent niacinamide for 12 weeks in 50 women aged 40 to 60, documenting significant reductions in fine lines, hyperpigmentation spots, blotchiness, and yellowing [13]

Prapanthadara L, Promtet N, Koottathep S, Somboon P, Suwonkerd W, McCarroll L, et al