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9 Emerging therapeutic interventions targeting metabolism and mitochondria 9.1 Metabolic modulators 9.1.1 Intranasal insulin Central nervous system (CNS) insulin deficiency may result from impaired insulin transport across the blood-brain barrier (BBB)

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Formulations of GLP-1 with extended duration The enzyme DPP-4 is responsible for the rapid inactivation of GLP-1, although some GLP-1 is also removed from the circulation by renal clearance and by the enzyme neutral endopeptidase [11]

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