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Current protocols recommend treating patients with an initial dose of 150 mg/kg NAC, infused over a period of an hour, upon hospitalization, followed by decreasing amounts of NAC infused over the next 20 hours

These side effects tend to occur early in treatment and often improve with dose escalation strategies and behavioral measures

In one sentence, the mechanism is receptor-mediated: GHRP binding to GHS-R1a activates a Gq/11-coupled phospholipase C cascade that mobilises intracellular calcium and triggers exocytosis of stored GH from the anterior pituitary, independent of hypothalamic GHRH signalling