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Vitamin B (pyridoxine), when chronically taken in gram quantities, is known to cause a sensory neuropathy, numbness and tingling in the extremities, but the amount of B in this formula (2 mg per mL) is far below such neurotoxic levels

J Dent 17(1):2125 Ebrahimi S, Hashemy SI (2019) MicroRNA-mediated redox regulation modulates therapy resistance in cancer cells: clinical perspectives

This is one of the earliest signs that the injection is helping your body produce more red blood cells and improving oxygen transport

If youre experiencing persistent darkening or irritation, it may be helpful to consult with a dermatologist to understand your skins needs better