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Barnes RP, de Rosa M, Thosar SA, Detwiler AC, Roginskaya V, Van Houten B, et al

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At 72 weeks: 62.9% of semaglutide patients achieved resolution of MASH without worsening of fibrosis, compared to approximately 34% on placebo Semaglutide demonstrated significant improvements in both MASH activity and liver fibrosis an outcome that distinguished it from the Phase 2 results where fibrosis improvement was less clear On August 15, 2025, the FDA granted accelerated approval to semaglutide (Wegovy