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Efficacy and safety of once-weekly GLP-1 receptor agonist albiglutide (HARMONY 2): 52 week primary endpoint results from a randomised, placebo-controlled trial in patients with type 2 diabetes mellitus inadequately controlled with diet and exercise

Larger and more diverse patient cohorts are needed, lower dosages of semaglutide have to be tested, and follow-ups need to be conducted beyond 26 weeks.

9 Conclusion GLP-1 receptor agonists have emerged as revolutionary therapeutic agents in the treatment of T2DM and obesity, exhibiting significant effectiveness via their multi-faceted activities

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