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The number of reported serious side effects was 13.73% with semaglutide 3 mg, 10.13% with semaglutide 7 mg, 9.46% with semaglutide 14 mg, and 12.45% with sitagliptin 100 mg.In PIONEER 4,188 the rate of adverse side effect was 51.93% with semaglutide 14 mg, 42.25% with liraglutide 1.8 mg and 33.10% with placebo The number of reported serious side effects was 10.88% with semaglutide 14 mg, 7.75% with liraglutide 1.8 mg and 10.56% with placebo